Featured Journal – Journal of Organic Chemistry


Today, I thought I’d pick a featured journal which all you organic chemists will have definitely heard of, and will most likely have referenced yourself.

This journal does exactly what it says on the tin. Journal of Organic Chemistry aims to publish original fundamental research in all areas of theoretical and practical organic chemistry, and is the go-to journal for many organic chemists.

With an impact factor of 4.564, JOC is the most cited organic chemistry journal, and had 96,723 cites in 2012. It accepts brief communications that showcase urgent chemistry of unusual novelty, full articles, reviews, notes and perspectives. They also include one featured article every issue, which is chosen for its significant contribution to organic chemistry research.

You can see the latest issue of JOC here, but you may need a subscription to view all of the content.

In Journal of Organic Chemistry today:

“Boronic Esters in Asymmetric Synthesis”


Boron compounds are becoming increasingly popular reagents in organic chemistry, and this review highlights examples of the use of haloalkylboronic acids in asymmetric synthesis. As most chemists know, installing stereocentres is a tricky aspect of synthesis, and this procedure allows for excellent control of several stereocentres in a range of compounds. Organoboron chemistry is still developing as a field, and many organic chemists could benefit from embracing these syntheses in their research.

“Biomimetic Total Syntheses of Borreverine and Flinderole Alkaloids”


Total synthesis of natural products has always been an active area of organic chemistry, as researchers strive to devise an elegant route to complex molecules. Here, we’re presented with total syntheses of two classes of compounds, using biomimetic approaches. Borreverines and flinderoles are an interesting class of alkaloids which show potent anti-malarial activity, and so are attractive targets for total synthesis. What’s particularly interesting is the clever use of cycloaddition reactions to construct very complicated molecules.

“Molecular “Pincer” from a Diimidazolium Salt: Study of Binding Ability”


Anion binding is a topic seen more in areas such a supramolecular chemistry, but here we see it in a molecular context. It’s a very popular research area, because of the possible applications in catalysis, anion recognition and extraction and biological processes. This paper studies the binding ability of a molecular pincer compound which shows a high affinity for binding carboxylate anions. This is a bit different from articles typically seen in organic chemistry journals, and this chemistry could prove to be very useful.

“Direct Preparation of Nitriles from Carboxylic Acids in Continuous Flow”


The nitrile functional group is a key intermediate in many organic syntheses, and has many uses in the formation of heterocyclic molecules. This paper describes a method of synthesising organic nitriles in a continuous flow reactor, using the unusual solvent of supercritical acetonitrile. Flow chemistry is becoming increasingly popular, in both academia and industry, as it can have many benefits over traditional batch reactors, both economically and environmentally. This is an interesting and cool new way to form very useful compounds.

Journal of Organic Chemistry covers all areas of organic chemistry, and the wide range of topics it includes makes it a vital source of information for many researchers.


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